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Scientific studies

The studies will help the diagnostic and treatment of infertility patients in the future.

Nova Vita Clinic has always participated in research projects related to human infertility. Our aim is to investigate the reasons of the female and male infertility and help to work out better solutions to help infertile couples.

Nova Vita is a partner of Competence Centre on Health Technologies and works in close cooperation with Finnish IVF clinic Ovumia.

NovaVita Clinic is from 01.01.2016 – 31.08.2022 a partner of The Competence Centre on Health Technologies (CCHT) research and development project CCHT (Competence Centre on Health Technologies, EU48695).  Nova Vita Clinic project related development activities are co-funded by European Regional Development Fund with 96 589 €. The  CCHT project is a part of Competence Centres programme.

Enterprise Estonia
  1. PhD thesis”Genes Regulated by Estrogen and Progesterone in Human Endometrium”. Karin Rosenstein, Tallinn University of Technology. 2016.
  2. Endometrial transcriptome analysis indicates superiority of natural over artifical cycles in recurrent implantation failure patients undergoing frozen embryo transfer. Altmäe S, Tamm-Rosenstein K, Esteban FJ, Simm J, Kolberg L, Peterson H, Metsis M, Haldre K, Horcajadas JA, Salumets A, and Stavreus-Evers A. Reproductive BioMedicine Online. 2016.
  3. Systemic oxidative stress could predict assisted reproductive technique outcome. Ahelik A, Mändar R, Korrovits P, Karits P, Talving E, Rosenstein K, Jaagura M, Salumets A, Kullisaar T. J Assist Reprod Genet. 2015 May; 32(5):699-704. doi: 10.1007/s10815-015-0466-6. Epub 2015 Mar 28.
  4. Changes in the Transcriptome of the Human Endometrial Ishikawa Cancer Cell Line Induced by Estrogen, Progesterone, Tamoxifen, and Mifepristone (RU486) as Detected by RNASequencing. Tamm-Rosenstein K, Simm J, Suhorutšenko M, Salumets A, Metsis M. (2013).. PLoS ONE, 8, e68907.
  5. The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland. Tamm K, Suhorutshenko M, Rõõm M, Simm J, Metsis M. (2012). Steroids – Basic Science (35 – 64). InTech – Open Access Publisher.
  6. Suguhormoonide östradiooli ja progesterooni koespetsiifiline roll inimese endomeetriumis ja rinnanäärmes. Tamm K, Suhorutšenko M, Talving E, Kaljas A, Metsis M. (2012). Eesti Arst, 91(4), 182 – 189.
  7. Genes targeted by the estrogen and progesterone receptors in the human endometrial cell lines HEC1A and RL95-2. Tamm K, Rõõm M, Salumets A, Metsis M. (2009). Reproductive biology and endocrinology, 7(170), 1 – 12.
  8. Variations in folate pathway genes are associated with unexplained female infertility. Altmäe S, Stavreus-Evers A, Ruiz JR, Laanpere M, Syvänen T, Yngve A, Salumets A, Nilsson TK. Fertil Steril. 2009 Mar 24. [Epub ahead of print]
  9. Incontinentia pigmenti in a female conceived by in vitro fertilization. Haller-Kikkatalo K, Peters M, Kisand K, Sõritsa A, Reimand T, Salumets A. Am J Med Genet A. 2008 Dec 1;146A(23):3092-4. No abstract available.
  10. Anti-FSH antibodies associate with poor outcome of ovarian stimulation in IVF. Haller K, Salumets A, Uibo R. Reprod Biomed Online. 2008 Mar;16(3):350-5.
  11. Circulating anti-follicle-stimulating hormone immunoglobulin A in women: a sperm-prone reaction of mucosal tolerance? Haller K, Sikut A, Karro H, Uibo R, Salumets A. Fertil Steril. 2008 Oct;90(4):1253-5. Epub 2007 Dec 26.
  12. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. Rull K, Hallast P, Uusküla L, Jackson J, Punab M, Salumets A, Campbell RK, Laan M. Mol Hum Reprod. 2008 Jan;14(1):23-31. Epub 2007 Nov 29.
  13. Cytogenetic and molecular characterization of the derivative Y chromosome: a case study of an azoospermic patient. Roovere T, Peters M, Horelli-Kuitunen N, Mölter-Väär T, Punab M, Rootsi S, Poolamets O, Salumets A. Clin Genet. 2007 Nov;72(5):460-3.
  14. Androgen receptor gene haplotype is associated with male infertility. Saare M, Belousova A, Punab M, Peters M, Haller K, Ausmees K, Poolamets O, Karro H, Metspalu A, Salumets A. Int J Androl. 2008 Aug;31(4):395-402.
  15. The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. Merisalu A, Punab M, Altmäe S, Haller K, Tiido T, Peters M, Salumets A. Fertil Steril. 2007 Oct;88(4):854-9. Epub 2007 Jun 7.
  16. Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization. Altmäe S, Haller K, Peters M, Hovatta O, Stavreus-Evers A, Karro H, Metspalu A, Salumets A. Mol Hum Reprod. 2007 Aug;13(8):521-6. Epub 2007 May 30.
  17. VNTR I/I genotype of insulin gene is associated with the increase of follicle number independent from polycystic ovary syndrome. Haller K, Laisk T, Peters M, Talving E, Karits P, Karro H, Uibo R, Salumets A. Acta Obstet Gynecol Scand. 2007;86(6):726-32.
  18. Putative predictors of antibodies against follicle-stimulating hormone in female infertility: a study based on in vitro fertilization patients. Haller K, Salumets A, Grigorova M, Talja I, Salur L, Béné MC, Laan M, Uibo R. Am J Reprod Immunol. 2007 Mar;57(3):193-200.
  19. Controlled ovarian hyperstimulation changes the prevalence of serum autoantibodies in in vitro fertilization patients. Haller K, Sarapik A, Talja I, Salumets A, Uibo R. Am J Reprod Immunol. 2006 Nov-Dec;56(5-6):364-70.
  20. Frozen embryo transfers: implications of clinical and embryological factors on the pregnancy outcome. Salumets A, Suikkari AM, Mäkinen S, Karro H, Roos A, Tuuri T. Hum Reprod. 2006 Sep;21(9):2368-74. Epub 2006 May 9.
  21. Elevated incidence of chromosomally chaotic embryos among frozen-thawed preimplantation embryos. Salumets A, Horelli-Kuitunen N, Suikkari AM, Metspalu A, Tuuri T. Eur J Obstet Gynecol Reprod Biol. 2004 May 10;114(1):59-63.
  22. Effect of developmental stage of embryo at freezing on pregnancy outcome of frozen-thawed embryo transfer. Salumets A, Tuuri T, Mäkinen S, Vilska S, Husu L, Tainio R, Suikkari AM. Hum Reprod. 2003 Sep;18(9):1890-5.
  23. Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures. Salumets A, Hydén-Granskog C, Mäkinen S, Suikkari AM, Tiitinen A, Tuuri T. Hum Reprod. 2003 Apr;18(4):821-5.
  24. Influence of oocytes and spermatozoa on early embryonic development. Salumets A, Suikkari AM, Möls T, Söderström-Anttila V, Tuuri T. Fertil Steril. 2002 Nov;78(5):1082-7.
  25. The predictive value of pronuclear morphology of zygotes in the assessment of human embryo quality. Salumets A, Hydén-Granskog C, Suikkari AM, Tiitinen A, Tuuri T. Hum Reprod. 2001 Oct;16(10):2177-81.